Migraine headache is one of the most disabling neurologic disorders, with a lifetime prevalence of 33% in women and 13% in men worldwide. In a third of cases, patients will have an aura, which can manifest with visual phenomena or paresthesias, typically in the hand or oral area. The headache is typically moderate to severe and can be associated with other symptoms such as photophobia, phonophobia, neck pain, nausea, emesis, and cutaneous allodynia. The headache is typically unilateral, throbbing, and worsened by movement, and it commonly lasts 1 to 24 hours or more.