Compartment syndrome is an elevation of the interstitial pressure in a closed osteofascial compartment that results in microvascular compromise. Compartments with relatively noncompliant fascial or osseous structures most commonly are involved, especially the anterior and deep posterior compartments of the leg (Fig. 48.1) and the volar compartment of the forearm. Compartment syndrome can develop anywhere skeletal muscle is surrounded by substantial fascia, however, such as in the buttock, thigh, shoulder, hand, foot, arm, and lumbar paraspinous muscles.