Although routine radiography currently remains the primary imaging modality in orthopaedics, more advanced imaging techniques are now an integral part of the modern orthopaedic practice. Modalities such as magnetic resonance imaging (MRI), computed tomography (CT), and ultrasonography (US) are valuable diagnostic tools and are fundamental components of image-guided interventional procedures. The scope of these advanced imaging techniques across the field of orthopaedics is far too broad to address in a single chapter. Therefore, this chapter provides a brief synopsis of the use of MRI and CT in orthopaedics. Musculoskeletal US is reviewed in various chapters as appropriate.