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Osteoporosis monitoring, diagnosis, and treatment algorithm for patients with Duchenne muscular dystrophy. BMD, Bone mineral density; DMD, Duchenne muscular dystrophy; DXA, dual-energy x-ray absorptiometry. ∗Signs of clinically significant bone fragility are low-trauma fractures of long bones or vertebrae.†Clinical stability refers to absence of nonvertebral fractures, stable healed vertebra fractures, absence of new vertebral fractures in previously normal vertebral bodies, absence of bone and back pain, and BMD Z score appropriate for height Z score or higher than 2 standard deviations.

出典

img 1:  Modified from Birnkrant DJ, Bushby K, Bann CM, et al: Diagnosis and management of Duchenne muscular dystrophy, part 2: respiratory, cardiac, bone health, and orthopaedic management, Lancet Neurol 17:347, 2018.